The fact that furfural is involved in the natural process of sexual spore germination of N. Here, we searched for new genetic attributes in the fungus Neurospora crassa that may be linked to furfural tolerance. Detoxification of furfural is thus important for efficient fermentation. Following plant biomass pretreatment, the furan derivative furfural is present at concentrations which are inhibitory to yeasts. « lessīackground: Biofuels derived from lignocellulosic biomass are a viable alternative to fossil fuels required for transportation. This study further underlines the need to consider presynaptic, non-receptor-mediated effects in human risk assessment. of Health (NIH) (United States) Ministry of Economy and Competitiveness (Spain) OSTI Identifier: 1378742 Grant/Contract Number: AC02-05CH11231 GM060468 2011-29297/AGR Resource Type: Accepted Manuscript Journal Name: Molecular BioSystems Additional Journal Information: Journal Volume: 12 Journal Issue: 2 Journal ID: ISSN 1742-206X Publisher: Royal Society of Chemistry Country of Publication: United States Language: English Subject: 59 BASIC BIOLOGICAL SCIENCES drug targets time-series analysis ROS membrane remodeling = and exocytosis. of Alicante (Spain) Sponsoring Org.: USDOE National Inst.
of California, Berkeley, CA (United States) Univ. Publication Date: Tue Dec 01 00:00: Research Org.: Univ. of California, Berkeley, CA (United States). for Environmental Studies (MIES) Ramon Margalef, Dept. of Plant Pathology, Multidisciplinary Inst. Finally, our results are of paramount importance for more » developing chitosan as an antifungal. Growth of NCU10610 (fig 1 domain) and SYT1 (a synaptotagmin) deletion strains was significantly increased by Ca 2+ in the presence of chitosan. Ca 2+ increased tolerance to chitosan in N.
NCU10521, a glutathione S-transferase-4 involved in the generation of reducing power for scavenging intracellular ROS is also a determinant chitosan gene target. Deletion strain analysis of chitosan susceptibility pointed NCU03639 encoding a class 3 lipase, involved in plasma membrane repair by lipid replacement, and NCU04537 a MFS monosaccharide transporter related to assimilation of simple sugars, as main gene targets of chitosan. Activation of oxidative metabolism indicates the importance of ROS and cell energy together with plasma membrane homeostasis in N. Global network analyses showed membrane, transport and oxidoreductase activity as key nodes affected by chitosan. crassa to chitosan and identified the main gene targets involved in the cellular response to this compound. In this paper, we have determined the transcriptional profile of N. Chitosan causes plasma membrane permeabilization and induction of intracellular reactive oxygen species (ROS) in Neurospora crassa. Chitosan is a natural polymer with antimicrobial activity.
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